Effect of Heinz bodies on red cell deformability.

Decreased deformability of acetyldamaged cells, in an all-or-none phenylhydrazine-treated erythrocytes, fashion. In mixtures, separation of unmeasured by in vitro filtration experitreated cells from Heinz body-containments, was found to parallel Heinz ing erythrocytes could be accombody formation. The decreased deplished by filtration. There may be a formability seemed unrelated to merelationship of these filtration propthemoglobin formation, ATP depletion, erties to intravascular, in vivo destrucred cell size, or membrane effect. tion of severely damaged cells in Hemolysis of Heinz body erythrocytes Heinz body anemias. occurred during filtration of severely